Wednesday, February 27, 2008

Russia revolutionises its jet industry


By Duncan Bartlett
Business reporter, BBC News, Moscow

Russia is hoping to make a giant come-back in civil and military aviation.

It has pledged to spend billions of dollars on boosting its defence industry, especially the air force.

The goal is to build nearly 6,000 new military and civilian aircraft, and to win 15% of the global aviation market.

Russia has set up a new government-controlled company to oversee the process, the United Aircraft Corporation.

But there's a long way to go, as Russia's aircraft industry has been in the doldrums since the collapse of the Soviet Union in the early 1990s.

New orders

President Vladimir Putin recently described Russia's aviation and space industry as "the pride of our country".


Can you tell me which country is not re-arming now?
Oleg Federov, Sukhoi commercial director

His government is in the process of re-organising much of the industry, which used to be made up of many separate firms such as the commercial aircraft maker Tupolev and Sukhoi, which makes Russia's famous MiG fighter jets.

Now they are all part of the new state-controlled United Aircraft Corporation.

And that's a good thing, according to Sukhoi's commercial director, Oleg Federov.

"We've already received new orders for military fighters and for our civil products, and we are overloaded until 2015," he says.

"It's good for jobs, it's good for our workshops, it's good for the future."

Old planes

Mr Federov's company may be busy, but there remains a lot of catching up to do.


Russia has money and the government is ready to invest because it expects a return on that investment
Oleg Pantaleev, aviation expert

Oleg Pantaleev, one of Russia's leading aviation experts and the editor of the website Aviaport, admits that large parts of the industry remain out-dated and inefficient.

"The problem is that there are so many old models created in the 1980s and 1990s," he says.

"They are not comparable with Western aircraft because they use a lot more fuel. On the other hand, they are cheaper - maybe 20% or 30% cheaper than the Western planes."

Mr Pantaleev believes that ultimately the United Aircraft Corporation will be successful, but not within the tight deadlines that the government has set the company.

"Russia has money and the government is ready to invest because it expects a return on that investment," he says.

New weapons

Critics have regarded Russia's new arms build up with suspicion, but the Kremlin's supporters insist it's not a threat.

"Why shouldn't Russia build up its defence if everybody else does?," says professor Alexei Pushkov, a political commentator and the presenter of a well-known Russian current affairs television programme, Post Scriptum.

Mr Pushkov points to the US military budget, which dwarfs that of Russia.

"Everybody in the West talks about Russia re-arming itself and are hardly noticing what's going on on the other side of the ocean," he says.

"Russia is a huge country, it has to defend its borders. We have a border of 4,500km with China, so Russia has to build up its military. This right should be recognised."

'Not enemies'

President Putin recently warned that Nato and the West were provoking Russia into a new arms race.

So, is that a sign that the chilly relations with the West are turning into a new Cold War?

Not according to Sukhoi's Mr Federov.

"Russia and the US are not enemies, we have normal relations," he says.

"Can you tell me which country is not re-arming now? I think it's not just a question of Russia, or the US, or Great Britain. The government of each country is responsible for updating and providing new technology within the military."

President Putin wants the United Aircraft Corporation to become what he calls "a national champion", a major company which will develop into an important international player.

But a good deal more hard work and investment are required before it can begin to be taken seriously as a rival to European and American companies such as Airbus and Boeing.

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/business/7266853.stm

Published: 2008/02/28 00:01:38 GMT

© BBC MMVIII

Wednesday, February 20, 2008

Lâmpada a gravidade é um invento “verde”


Uma massa a descer cria energia suficiente para acender dez LED dentro da lâmpada, iluminando como se fosse uma lâmpada de 40 watts.
O invento faz parte da tese de mestrado de Clay Moulton, nos EUA. A lâmpada, Gravia, não se liga à corrente eléctrica, funcionando com a gravidade. Passemos a explicar: uma massa no interior da lâmpada, ao mover-se para baixo, graças à gravidade, cria energia para iluminar os dez LED aí existentes.

Mede perto de 1,2 metros e não necessita de qualquer fio, visto a energia ser produzida pela gravidade. A iluminação conseguida é de 600 a 800 lumens, o equivalente a 40 watt de uma lâmpada incandescente em durante quatro horas.

Moulton estima que o seu invento dure 200 anos, sendo usado durante 8 horas por dia, nos 365 dias do ano.

Thursday, February 14, 2008

Virus immunity 'created in lab'


Scientists have found a way to boost an organism's natural anti-virus defences - effectively making its cells immune to flu and other potential killers.

The process cannot be carried out in human cells - but it could potentially aid the development of effective new anti-viral therapies.

It works by stimulating production of the protein interferon, the cell's first line of defence against viruses.

The study, led by Canada's McGill University, appears in Nature.


The varying forms of the flu virus have killed millions of people down the years, and scientists are concerned that the H5N1 strain of the virus, which currently is overwhelmingly a disease of birds, could mutate to pose a grave threat to human populations across the globe.

Other viruses, such as Sars, have also sparked global health alerts in recent years.

The researchers knocked out two key genes in mice that repress production of interferon.

Brakes off

With these genes out of action, the mouse cells produced much higher levels of interferon, which effectively blocked viruses from reproducing.

Tests on four viruses, including that responsible for flu, produced highly promising results.

Lead researcher Dr Nahum Sonenberg said: "People have been worried for years about potential new viral pandemics, such as avian influenzas.

"If we might now have the means to develop a new therapy to fight flu, the potential is huge."


Dr Mauro Costa-Mattioli, who also worked on the study, said: "In a sense, it is quite a simple story.

"When you get rid of the repressors, you are basically removing the brakes."

The researchers detected no abnormalities or negative side-effects resulting from enhanced interferon production in the mice.

They are optimistic that new drugs can be developed which target the same two key genes in humans.

Professor John Oxford, a virology expert at Queen Mary College School of Medicine, London, said the paper was impressive.

He said: "Boosting the innate immune system seems like a good idea - it has a huge practical application in theory."

But, citing the failed drug trials in North London two years ago which left several young men fighting for their lives, he added: "It could be a double-edged sword.

"You have to be jolly careful that you don't end up on Queer Street."

Monday, February 11, 2008

Prostate cancer screening 'hope'


UK researchers have discovered seven new genes associated with prostate cancer, which could be used to identify high-risk men more accurately.

Some of the genes could also lead to new treatments, the study in Nature Genetics suggests.

A trial is starting later this year to screen for the risk genes in men with a family history of the cancer.

The genes, found through analysis of 10,000 individuals, are present in over half of all prostate cancer cases.

Prostate cancer is the most common cancer in men in the UK.


From a public health point of view, this could be very helpful because it will allow us to target scarce resources to where they are really needed
Dr Ros Eeles

There is currently no routine screening programme in the UK, although men with a family history of the disease can have a prostate specific antigen (PSA) blood test to detect signs of the disease.

But this is notoriously inaccurate and although 10-15% of men will have high enough PSA levels to warrant carrying out a prostate biopsy, only 2-3% will require any treatment.

Genome-wide scan

More than half a million single letter variations in the DNA code were analysed in men in the UK and Australia.

Researchers said the seven genes they found had not previously been linked to prostate cancer.

One of them, MSMB, can be measured in the blood and may be particularly helpful in screening for or monitor progression of the disease.

Another, LMTK2, is a potential target for new treatments, the researchers said.

Within three to four years, it should be possible to offer "genetic profiling" to men to assess their risk of developing the condition, the researchers believe.

It will enable doctors to more accurately decide which men need more regular monitoring or a biopsy.

Dr Ros Eeles, who led the study at the Institute of Cancer Research said: "From a public health point of view, this could be very helpful because it will allow us to target scarce resources to where they are really needed.

She said genetic profiling would definitely happen but researchers were not in a position to offer the test just yet.

"We're doing the trial because we need to see who would come forward for the test, who would benefit, what kind of results do they get on their biopsies and what kind of cancer develops."

Professor Doug Easton, genetic epidemiology expert at the University of Cambridge, who analysed the data said the results would "greatly improve" the understanding of how prostate cancer develops.

He added that most people would have at least one of the genes but it was the combination of a few that would increase a persons' risk above the population average.

Targets

Nick James, professor of clinical oncology at the University of Birmingham and consultant in clinical oncology at the Queen Elizabeth Hospital, said it had proved much more difficult to find genes in prostate cancer compared with some other cancers.

He said: "This work provides two useful avenues."

"One is that finding faulty genes gives researchers a chance to look at their products that may be good targets for new treatments.

"Secondly, this discovery may mean that we can target screening for prostate cancer - a process that has been very controversial due to over diagnosis of clinically insignificant cancer - to groups of men that we know to have higher risk of developing the disease."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7234922.stm


Tuesday, February 5, 2008

Three-parent embryo formed in lab


Scientists believe they have made a potential breakthrough in the treatment of serious disease by creating a human embryo with three separate parents.

The Newcastle University team believe the technique could help to eradicate a whole class of hereditary diseases, including some forms of epilepsy.

The embryos have been created using DNA from a man and two women in lab tests.

It could ensure women with genetic defects do not pass the diseases on to their children.


It is human beings they are experimenting with
Josephine Quintavalle
Comment on Reproductive Ethics

The technique is intended to help women with diseases of the mitochondria - mini organelles that are found within individual cells.

They are sometimes described as "cellular power plants" because they generate most of the cell's energy.

Faults in the mitochondrial DNA can cause around 50 known diseases, some of which lead to disability and death.

About one in every 6,500 people is affected by such conditions, which include fatal liver failure, stroke-like episodes, blindness, muscular dystrophy, diabetes and deafness.

At present, no treatment for mitochondrial diseases exists.

Genetic transplant

The Newcastle team have effectively given the embryos a mitochondria transplant.


We believe we could develop this technique and offer treatment in the forseeable future that will give families some hope of avoiding passing these diseases to their children
Professor Patrick Chinnery
University of Newcastle

They experimented on 10 severely abnormal embryos left over from traditional fertility treatment.

Within hours of their creation, the nucleus, containing DNA from the mother and father, was removed from the embryo, and implanted into a donor egg whose DNA had been largely removed.

The only genetic information remaining from the donor egg was the tiny bit that controls production of mitochondria - around 16,000 of the 3billion component parts that make up the human genome.

The embryos then began to develop normally, but were destroyed within six days.

Appearance

Experiments using mice have shown that the offspring with the new mitochondria carry no information that defines any human attributes.

So while any baby born through this method would have genetic elements from three people, the nuclear DNA that influences appearance and other characteristics would not come from the woman providing the donor egg.

However, the team only have permission to carry out the lab experiments and as yet this would not be allowed to be offered as a treatment.

Professor Patrick Chinnery, a member of the Newcastle team, said: "We believe that from this work, and work we have done on other animals that in principle we could develop this technique and offer treatment in the forseeable future that will give families some hope of avoiding passing these diseases to their children."

Dr Marita Pohlschmidt, of the Muscular Dystrophy Campaign, which has funded the Newcastle research, was confident it would lead to a badly needed breakthrough in treatment.

"Mitochondrial myopathies are a group of complex and severe diseases," she said.

"This can make it very difficult for clinicians to provide genetic counselling and give patients an accurate prognosis."

However, but the Newcastle work has attracted opposition.

Josephine Quintavalle, of the pro-life group Comment on Reproductive Ethics, said it was "risky, dangerous" and a step towards "designer babies".

"It is human beings they are experimenting with," she said.

"We should not be messing around with the building blocks of life."

Mrs Quintavalle said embryo research in the US using DNA from one man and two women was discontinued because of the "huge abnormalities" in some cases.

Dr David King, of Human Genetics Alert, expressed concern about a "drift towards GM babies".

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7227861.stm

Published: 2008/02/05 11:13:29 GMT

© BBC MMVIII

Sunday, February 3, 2008

The New Food Capital Of The World


NEWSWEEK
Updated: 11:46 AM ET Feb 2, 2008

Toru Okuda was in trouble. He'd slaved away for years to realize his dream of opening a gourmet restaurant in Tokyo, and by 2003 he had finally pulled it off. He'd even managed to land an address for his place, dubbed Koju, in the high-rent district of Ginza—quite an achievement for a thirtysomething from provincial Shizuoka. But just a few months after opening, Okuda realized that one critical ingredient was still missing: customers. "On some days we only had two or three," he recalls. "My cooks and I had to eat all the food. I should have enjoyed it, but it was sticking in my throat." Bankruptcy threatened.

But Okuda persevered, serving impeccably prepared delicacies like charcoal-grilled blowfish and fresh snow crab topped with roe. And this past November he received his reward. Paris-based Michelin, publisher of the world's most authoritative restaurant guides, announced it was awarding him and seven other Tokyo restaurateurs its highest distinction, three stars, rocketing them into the stratosphere of international gastronomy. Okuda's business has since turned around. And he won't be lonely at the top. Michelin's first guide to the Japanese capital—its first devoted to anyplace in Asia, in fact—has made official what many foodies have long suspected: that the center of culinary gravity has shifted to the Land of the Rising Sun. Japan is a food-crazy nation like few others, and it's finally getting the attention it deserves. "We have the best food on the planet," says British restaurant critic and longtime resident Robbie Swinnerton, who has written about Japanese food for two decades. "We knew that for a long time. Now the rest of the world is catching [on]."

Still, the scale of Tokyo's dominance will stun most outsiders. Jean-Luc Naret, the director of the Michelin Guide, knew something extraordinary was up when he and his team of Tokyo inspectors sat down last year after doing their initial reviews and realized that, "for the first time in history," they had enough starred restaurants to fill an entire volume. (Normal Michelin Guides include a selection of notable unstarred restaurants as well as top-rated establishments.) The guide ultimately gave a total of 191 stars to Tokyo, leaving Paris a distant second with 97 and New York third with 54. In fact, Tokyo outshone entire nations with notable culinary pedigrees, including Spain and Portugal combined (133).

Not surprisingly, the publication of the guide has sparked a huge and entertaining controversy. After its appearance, many Japanese critics fretted that European inspectors hadn't comprehended the quirky specifics of Japan's food culture, leaving great restaurants off the list and ignoring masters in favor of their apprentices—a violation of Japan's veneration of seniority. WHAT DO THEY KNOW ABOUT JAPANESE CUISINE? asked the tabloid Nikkan Gendai in a headline in late November. Even some of the chefs who ultimately got good ratings complained (anonymously) that the foreigners hadn't managed to understand classical traditions of subtlety and simplicity; Michelin says that its team included several Japanese experts, but never mind. The Japanese were persnickety even when it came to foreign cuisine; some said Michelin went too easy on French restaurants in Tokyo, while others claimed it was too harsh. Others said Michelin was pandering to Japanese readers: one TV commentator even accused it of "star inflation."

In Paris, Le Figaro announced the news with the headline "Tokyo, New World Center of Gastronomy," and warned: "Paris, which is far behind, better watch out." For months, the article noted, the restaurant world had been anticipating the arrival of Michelin's Tokyo guide, "but no one imagined the explosion that the results of this publication would cause."

Then the damage control operation began. Commentators pointed out that Paris still ranks first in three-star restaurants, with 10 to Tokyo's eight (and New York's three), and that Paris has only about one third as many people as greater Tokyo, so if you count stars on a per capita basis, Paris still wins. Besides, as noted French chef Alain Senderens says, the whole obsession with Michelin stars is elitist and out of date—a fusty honor bestowed largely on overpriced restaurants that still do "starched tablecloths" and "giant napkins."

If the French seem less than willing to face defeat, their old rivals are ready to draw the starkest conclusions. British food critic Giles Coren (interview) called the Michelin rulings an accurate read on a French civilization in "terminal decline."

Naturally, all the fuss has only made the public more interested. The first 90,000 copies of the Japanese edition sold out within 24 hours of publication—roughly the same number of sales that the New York guide got in its first year. And even though the book was published in November, it still ended up as a best seller for 2007. "It was like the debut of the latest 'Harry Potter'," says Naret with a laugh.

And why not? It's no exaggeration to say that the Japanese are crazy about their food. About a third of all TV broadcasts in Japan are devoted to the subject—from simple cooking shows to taste-test guessing games featuring blindfolded celebrities. Tokyo has 160,000 restaurants, compared with 13,000 in Paris. Japanese foodies happily stand in line for hours to garner sample delicacies or coveted restaurant seats. Japan food bloggers are hugely prolific, cataloging their meals in painstaking detail (and, often, with cell-phone photos). One housewife whose blog documents her quest for the country's best bread proudly notes that she's visited 384 bakeries in the city of Kobe alone.

Japan's restaurants reflect this obsession. Consider Sukiyabashi Jiro, which was already one of Tokyo's most famous sushi spots before Michelin gave it three stars for reasons that have nothing to do with starched tablecloths. Its 82-year-old owner, Jiro Ono, has spent the past 50 years perfecting his technique. "I've only been there once but I was stunned," says restaurant critic Jun Yokokawa. "It's the ultimate sushi." Ono meticulously controls the temperature of each type of fish he uses, in order "to bring out the best in each," and is famous for wearing gloves whenever he leaves the restaurant, even in summertime, to make sure he never loses his magical feel for fish.

His restaurant is all about the food; if you need to use the amenities, you'll have to go next door. Just because Ono got three stars, notes Michelin's Naret, he's unlikely to add toilets any time soon. "He's not going to put carpet on the floor, he's not going to put money into chandeliers. He's still going to invest in the best product, cutting the fish in a way you'll never see anywhere else."

There are many explanations for Japan's astounding fascination with food. Though the fact is often obscured by Japan's present prosperity, it's only been a generation or two since many people here still went hungry. Now that they have the means, modern Japanese indulge by building on deeply rooted traditions of obsessive craftsmanship and nature worship. Ingredients, and the seasons, are everything. At two-star Kikunoi, the water to make fragrant dashi broth is trucked in several times a week from a well owned by the restaurant's parent establishment in Kyoto. The bonito flakes that flavor the soup come from fish caught off the southern island of Kyushu and are carefully sliced to a thickness of one third of a millimeter. Another ingredient, top-quality kombu kelp from Hokkaido in the north, is dried in temperature-controlled storage, then in the open air, for more than a year before it makes it to Tokyo. "We try to use ingredients that are the best, superior to anything else available," says owner and head chef Yoshihiro Murata.

This is the ethic instructors strive to inculcate at Tokyo's elite Tsuji Culinary Institute—whether the cuisine at hand is elegant classical kaiseki or contemporary European. Students start off by learning how to stand properly in the kitchen while using a knife. There's no moving on to more-refined topics until they've mastered the proper way to cut vegetables, and some critics have compared the rote movements to martial-arts training. "You have to be so accurate when you slice ingredients," says Yuka Kakuta, 25. "I couldn't do it at first." Aspiring chefs also have to memorize everything from countless brands of rice and miso (soybean paste) to the myriad types of plates and bowls that go with different sorts of food. "There are plates that cannot be used during certain seasons," says Tsuji professor Kiyoshi Mitsuzono. "I tell my students to study [Japanese cuisine] just as you would study painting or music." The challenge seems all the more daunting considering that the Japanese notion of prime season, or shun, can be as fleeting as a week; bamboo shoots, for example, have a shun of just 10 days.

That sort of intensity surprises foreigners but has placed Japan at the cutting edge of world cuisine. "In Japan they take huge steps in choosing ingredients at the peak of flavor," says Alain Verzeroli, the head chef at Joël Robuchon, one of three French restaurants in Tokyo that got three stars. Verzeroli, who treats customers to Breton lobster and melt-in-your-mouth canard de Challans, heads an all-Japanese staff that includes several graduates of Tsuji's French campus, located just outside Lyon. Verzeroli pays particular credit to the connoisseurship of Japan's wine lovers—another surprise for outsiders—who have a knack for finding the world's best and importing it at reasonable prices. And he's found Tokyoites to be so interested in his restaurant that he's started offering a series of cooking demonstrations, where customers are invited to the kitchen to watch him prepare simple dishes that they can then sample in the restaurant.

Remarkable attention to detail is typical of Japanese gastronomy at all price levels. Even a $7 bowl of buckwheat noodles (at the century-old Kanda Matsuya soba restaurant) is made by hand, and served in broth freshly prepared each day from a base that's rested for 10 days. At the Tokyo tempura restaurant Miyagawa, where the chef's lunch menu costs just over $20, the head chef usually begins his day by working contacts at Tokyo's legendary Tsukiji fish market. A few weeks ago, he came up with special winter clams, which are fried in batter specially seasoned to bring out their taste. The clams weren't on display anywhere in the market, of course; "you have to know what you're looking for," he says.

Such restaurants make great Japanese food wonderfully accessible. Critic Yokokawa notes that the endless attention to cuisine in the media has helped create an atmosphere in which even ordinary restaurants compete for attention. "One great thing about Japan is that even everyday food has become sophisticated," he notes. He's struck, he says, by the number of Japanese who, when asked about their favorite hobbies, respond with the word tabearuki, meaning "eating and walking"—in other words, roaming around in search of new places to dine. "It's as if the entire population were foodies."

Tokyo restaurant owners aren't looking for only Japanese-style perfection. Tokyo has a certified National Austrian Cooking Master, Shingo Kanda, who is head chef at the marvelous K. und K. It also has a chevalier of the elite French fraternity of cheese experts, the Confrérie du Taste-Fromage—Katsuki Mori, the genius behind a wonderful Italian-Japanese fusion place called Esperia. The one-star Morimoto XEX teppanyaki restaurant offers tofu cheesecake and an appetizer of buffalo mozzarella, octopus carpaccio and Parma ham. Meanwhile, in the august Tokyo neighborhood of Kappabashi, stores sell kitchen equipment from all over the world, and can conjure up plastic replicas of any dish, from tacos to curry with nan.

The cross-pollination works both ways. Japan helped inspire the worldwide haute cuisine trend, which puts a premium on lightness and freshness, with tasting menus featuring many small but perfect creations. Now what some Tokyo food experts call "the Michelin effect" looks likely to extend this influence. In a 2007 Japanese government survey, 71 percent of foreign tourists in Japan cited food as a primary reason for their visit. One wonders why Michelin took so long to make the trip.

Ironically, world recognition comes close on the heels of domestic scandal. Last year brought revelations that a number of reputable Japanese companies had mislabeled food products from sweets to steak—in some cases by falsifying their due dates. Calls followed for a new consumer agency to tighten a lax regime of food inspections. A newspaper poll found that Japanese regarded the food scandal as the second most important story of 2007—behind only the surprise resignation of Prime Minister Shinzo Abe.

Despite the mess, however, Japanese food enthusiasts will find a way to soldier on. For one thing, they know that while Tokyo may now be considered the food capital of the world, it's definitely not the food capital of Japan. Michelin has yet to issue a guide for Kyoto, but that city is the real lodestar of Japanese culinary tradition. "If you apply the same standards there, I would not at all be surprised if Kyoto ended up with 10 to 20 three-star restaurants," says Yokokawa, who rates Tokyo "one rank lower than Kyoto." That, of course, would place it two ranks ahead of Paris.